A. Rodney White Скачать все книги 2 Количество книг

Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.

This second edition of a very successful vascular surgery text was developed in order to address significant changes that have occurred in contemporary vascular surgery and to highlight new information that has developed regarding vascular imaging, interventional and endovascular procedures. The overall length of the text is slightly shorter than the first edition with relevant core chapters being retained to emphasize the basic science nature of the text, with approximately 60% of the material undergoing major revisions or being new chapters. The significant change from the first text is an emphasis on vascular pathology and physiology that is relevant to current practice including information that is currently included on the vascular board examinations. A new emphasis on endovascular therapies has been added by including five chapters on endovascular techniques and an additional section with six chapters comparing conventional vascular reconstruction to endovascular methods. These new chapters address the most important issue in contemporary vascular surgery, i.e., the role of endovascular methods in treating vascular lesions and the impact that this has on training and credentialing. A unique aspect of this book differentiating it from other texts is a comparison of conventional methods with the endovascular techniques. Overall the text provides a comprehensive perspective of contemporary vascular surgery and future perspectives. The authors are preeminent in the field and are most capable for addressing the assigned topics with the goals being to provide an updated and forward looking text that accommodates the needs of practicing and training vascular surgeons.