A. Margaret Heffernan Скачать все книги 2 Количество книг

Second Edition features the latest tools for uncovering the genetic basis of human disease The Second Edition of this landmark publication brings together a team of leading experts in the field to thoroughly update the publication. Readers will discover the tremendous advances made in human genetics in the seven years that have elapsed since the First Edition. Once again, the editors have assembled a comprehensive introduction to the strategies, designs, and methods of analysis for the discovery of genes in common and genetically complex traits. The growing social, legal, and ethical issues surrounding the field are thoroughly examined as well. Rather than focusing on technical details or particular methodologies, the editors take a broader approach that emphasizes concepts and experimental design. Readers familiar with the First Edition will find new and cutting-edge material incorporated into the text: Updated presentations of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environment interactions A completely rewritten and updated chapter on determining genetic components of disease New chapters covering molecular genomic approaches such as microarray and SAGE analyses using single nucleotide polymorphism (SNP) and cDNA expression data, as well as quantitative trait loci (QTL) mapping The editors, two of the world's leading genetic epidemiologists, have ensured that each chapter adheres to a consistent and high standard. Each one includes all-new discussion questions and practical examples. Chapter summaries highlight key points, and a list of references for each chapter opens the door to further investigation of specific topics. Molecular biologists, human geneticists, genetic epidemiologists, and clinical and pharmaceutical researchers will find the Second Edition a helpful guide to understanding the genetic basis of human disease, with its new tools for detecting risk factors and discovering treatment strategies.

In this provocative book, Margaret Heffernan, former CEO and Fast Company contributor, fuses her own experience with that of hundreds of women to identify the biggest challenges and the best solutions that women face today. From VPs of Fortune 100 companies to entrepreneurs to women just starting their careers, she traces the patterns and themes underlying women's power, choices, love, sex, money, and many other vital topics for working women. Without sugar-coating the facts, preaching, or oversimplifying, she offers solutions and shares the truth about the working world: women's choices are limited, you can't have it all, women do work differently from men and, yes, it is possible to find success amidst all of this and feel good about it. «Finally! A book that exposes the masculine myths about what it takes to be effective in business and helps women reclaim the relational intelligence we have been taught to ignore. A must-read for all women who want to increase their power and influence in the workplace—especially those who are thinking of leaving because they are tired of the corporate gamesmanship that requires splitting themselves into a 'work me' and a 'home me.'» —Joyce K. Fletcher, professor of management, Simmons School of Management, Boston, Massachusetts Order your copy today!